Amide group

amide group is a functional group that contains a carbonyl group that is attached to a nitrogen atom or any compound that contains an amide functional group.

The amides are derived from carboxylic acid and amine, a carboxylic acid containing the -COOH group, and in an -OH part amide the group is replaced by a -NH2 group. If we want to go into more detail, we can say that primary amides can replace a hydrogen from ammonia with an acyl group. Hydrogen atoms from the amide group can be replaced with hydrocarbon radicals (alkyl or aryl) and produce alternative amides. NH2 hydrogen from amide can also be replaced with other acyl groups to form secondary amides or third amides. Cyclic secondary amides are known as imides. Amides are named using the radical name acyl and amide, for example the link CH3singleCONH2 is called acetyl amide or acetamide.

Amides as analytes are often analyzed without derivation. Many amine derivatives actually lead to amides, which behave better than amines in the chromatographic column. The amide group can be either present, derived, or produced in primary compounds such as barbiturates, diazepines, etc., or produced by heterocyclic amines such as acetylation after a previous derivation.

Finally, it is worth mentioning the name of the mineral anion NH2, which is the basis of the ammonia compound (NH3). Amides may be used to form resistant structural materials, such as nylon and collar. Dimethyl formamide is a very important organic solvent. Amides are also found in many drugs.

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